The unfolded protein response in bortezomib resistant myeloma cells
نویسندگان
چکیده
منابع مشابه
Response of myeloma to proteasome inhibitor bortezomib is correlated with unfolded protein response regulator XBP-1
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متن کاملPredicting the response of multiple myeloma to the proteasome inhibitor Bortezomib by evaluation of the unfolded protein response
Multiple myeloma (MM) remains a predominantly incurable malignancy despite high-dose chemotherapy, autologous stem cell transplant and novel agents. Proteasome inhibitors (PI) such as Bortezomib have increased the response rate and survival of patients with MM. The overall patient response rate of newly diagnosed MM to Bortezomib and Dexamethasone is about 67%. In relapsed refractory MM, the re...
متن کاملResponse of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1.
BACKGROUND Multiple myeloma, a malignancy of the antibody-secreting plasma cells, remains incurable by current therapy. However, the proteasome inhibitor bortezomib and other new drugs are revolutionizing its treatment. It remains unclear why myelomas are peculiarly sensitive to bortezomib, or what causes primary or acquired resistance. The 'unfolded protein response' is necessary for folding a...
متن کاملNovel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells
Tropolones are small organic compounds with metal-directing moieties. Tropolones inhibit the proliferation of cancer cell lines, possibly through their effects on metalloenzymes such as select histone deacetylases (HDACs). Pan-HDAC inhibitors are therapeutically beneficial in the treatment of multiple myeloma, however there is interest in the use of more selective HDAC inhibitor therapy to mini...
متن کاملCompromising the Unfolded Protein Response Induces Autophagy-Mediated Cell Death in Multiple Myeloma Cells
OBJECTIVE To determine whether the Unfolded Protein Response (UPR) sensors (PERK, ATF6 and IRE-1) can be targeted to promote death of Multiple Myeloma (MM) cells. METHODS We have knocked-down separately each UPR stress sensor in human MM cell lines using RNA interference and followed MM cell death by monitoring the membrane, mitochondrial and nuclear alterations. Involvement of caspases in MM...
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ژورنال
عنوان ژورنال: Pathology
سال: 2016
ISSN: 0031-3025
DOI: 10.1016/j.pathol.2015.12.193